Groebke reaction
WebNov 19, 2015 · In summary, the first practical applicable one-pot three-component catalyst-free Groebke reaction has been described. Imidazo [1,2-a] pyridine derivatives were … WebMicrowave-assisted synthesis of fused tetrazoleketopiperazine compounds via Ugi reactions
Groebke reaction
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WebMay 28, 2015 · The Groebke-Blackburn-Bienayme’ Reaction (GBBR) is a well-established multi-component method to form imidazoles using cyclic amidines. In order to expand … Web杂环化合物在医药、农业和工业中均有着广泛的应用。其中稠杂环化合物因其稳定的π共轭体系，常常作为荧光材料，广泛应用于染料、光电材料、荧光探针、荧光传感器等方面。咪唑并[1,2-a]吡啶作为一类重要的稠杂环化合物，是许多生物活性分子和药物中间体的核心骨架，可通过杂环脒、醛和异腈 ...
WebJan 1, 2010 · They usually lead to partially hydrogenated azolopyridines (X = CH, Hantzsch-type reaction) or azolopyrimidines (X = N, Biginelli-type reaction). Scheme 2 Aminoazoles as 1,3-binucleophiles Full size image Another type of multicomponent processes is isocyanide-based Groebke heterocyclization yielding fused imidazoles (Sub-group A 2 ). WebGroebke-Blackburn-Bienaymé multicomponent reactions can be efficiently catalysed by Brønsted acidic ionic liquids for the synthesis of imidazo [1,2- a ]pyridines and imidazo [2,1- b ]thiazoles in moderate to excellent yields (42–93 %), either under thermal or …
WebAug 30, 2024 · The Groebke-Blackburn-Bienaymé Reaction. André Boltjes [a] and Alexander Dömling* [a] Abstract: Imidazo[1,2-a]pyridine is a well-known scaffold in. many … WebA series of dimetallic ZnII‐LnIII compounds of general formulae [LnZn (L)3 (NO3)2]·2CH3OH (LnIII = DyIII (1), TbIII (2), GdIII (3)) prepared by stepwise reaction of compartmental ligand LH = (...
WebAug 30, 2024 · During the course of two decades the Groebke Blackburn Bienaymé (GBB-3CR) reaction has emerged as a very important multicomponent reaction (MCR), …
WebIn 1998, Professor Katrin Groebke, Hugues Bienaymé, and Christopher Blackburn reported a method for preparing imidazo [1,2-a]pyridine, in which an annulation took place among - aminopyridine, aldehyde, and isocyanide in one-pot operation, and then the reaction was entitled as Groebke reaction. jamestown women\\u0027s wrestlingWebThe Groebke-Blackburn-Bienaymé reaction (GBBR) is used for the one-pot synthesis of therapeutically relevant fused imidazoles bridgehead nitrogen heterocyclic compounds … lowes pinch clampsWebA chemically diverse set of 13 5-nitrofuran-tagged heterocyclic compounds has been prepared via the Groebke–Blackburn–Bienaymé multicomponent reaction. The testing of these compounds against the so-called ESKAPE panel of pathogens identified an apparent lead compound—N-cyclohexyl-2-(5-nitrofuran-2-yl)imidazo[1,2-a]pyridine-3-amine … lowes pilot programWebApr 14, 2024 · The eutectic mixture ChCl/urea was found to be both an eco-friendly and biodegradable solvent and an organo-catalyst able to promote the multicomponent synthesis of variously substituted 3-aminoimidazo-fused heterocycles 13 via Groebke–Blackburn–Bienayme (GBB) reaction, Scheme 5 . lowes pinch barWebA highly efficient and mild protocol for the synthesis of imidazo-fused polyheterocycles via Groebke–Blackburn–Bienaymè reaction under the influence of catalytic amount of lanthanum chloride heptahydrate has been described. A wide range of nitrogen-enriched polyheterocycles are synthesized with high yields under neat conditions. lowes pilot light switchWebIn 1998, Professor Katrin Groebke, Hugues Bienaymé, and Christopher Blackburn reported a method for preparing imidazo [1,2-a]pyridine, in which an annulation took place among - aminopyridine, aldehyde, and isocyanide in one-pot operation, and then the reaction was entitled as Groebke reaction. jamestown williamsburg virginiaWebIn 1998, Professor Katrin Groebke, Hugues Bienaymé, and Christopher Blackburn reported a method for preparing imidazo [1,2-a]pyridine, in which an annulation took place among - aminopyridine, aldehyde, and … jamestown women\u0027s basketball