Hepatocyte ferroptosis

Author: nvgv

August undefined, 2024

Web6 jul. 2024 · The purpose of this study was to investigate whether SiNPs caused hepatocyte ferroptosis and liver injury via ferritinophagy. In the in vivo study, SiNPs led to … Webthat ATF4 actually protected the liver against hepatocyte death and subsequent tumor formation. ... related ferroptosis, Journal of Hepatology (2024). DOI: 10.1016/j.jhep.2024.03.016

Frontiers Pharmacological modulation of ferroptosis as a …

Web30 mei 2024 · The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key … Web22 aug. 2024 · As mentioned above, ferroptosis was found in several types of tumor cells such as diffuse large B-cell lymphoma (DLBCL) (Kinowaki et al. 2024), renal cell … roll of rattan

Ferroptosis contribute to hepatic stellate cell activation and liver ...

Web10 nov. 2024 · By inhibiting hepatocyte ferroptosis, Fer-1 improves liver damage mediated by ALD, NAFLD, and hepatic ischemia/reperfusion (I/R) injury [29,76,99] . With in-depth … Web5 nov. 2024 · Hepcidin is a peptide hormone secreted by the liver that binds to and promotes the internalization and degradation of Ferroportin (Fpn), resulting in a diminished export of non-heme iron from tissues to the … Web4 mrt. 2024 · Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis. – Open Source Pharma … roll of raffle tickets

Ferroptosis contribute to hepatic stellate cell activation and liver ...

Web11 jul. 2024 · Ferroptosis (derived from the Greek word “ptosis”, meaning “a fall”, and Ferrum or iron) was first described in 2012 [1,2]. ... The instauration of hepatocyte … Web2 dagen geleden · "Our study suggests that ferroptosis may be the most relevant form of hepatocyte death that leads to inflammation, compensatory proliferation and cancer in … roll of recycled denimWeb21 mrt. 2024 · Ferroptosis is a form of iron-dependent regulated cell death and has two major hallmarks, intracellular iron overload and redox system disorder. The activation of … roll of red plastic table cover

"Web1 dag geleden · Despite being previously associated with advanced liver cancer, the researchers found that ATF4 actually protected the liver against hepatocyte death and … " - Hepatocyte ferroptosis

Hepatocyte ferroptosis

Ferroptosis: mechanisms, biology and role in disease

Web28 aug. 2024 · Objective: To explore the role and mechanism of haptoglobin (Hp) in hepatocyte ferroptosis. Methods: Thirteen 8-week-old C57BL/6J male mice were … Web18 aug. 2024 · Ferroptosis is a newly defined regulated cell death caused by iron-dependent lipid peroxidation. Our previous studies have shown that high glucose and …

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Web20 nov. 2024 · In turn, hepatocyte injury which lead to macrophage recruitment and HSC activation contribute to the disease pathogenesis [2]. Our finding that induction of … Web5 okt. 2024 · Ferroptosis was first identified in 2012 as a novel form of regulated cell death (RCD). It is characterized by excessive accumulation of intracellular lipid reactive oxygen species (ROS) and...

Web9 jan. 2024 · This, in turn, promotes hepatocyte ferroptosis during the event of acute liver injury, and also presumably leads to the progression of fibrosis. Therefore, … Web23 nov. 2024 · In physiological conditions, FPN is mainly expressed in the cytomembrane of Kupffer cells and hepatocytes around the portal vein (Drakesmith et al., 2015). Wang F …

WebLipid accumulation is exacerbated by lipid metabolism disorders, which contribute to the pathogenesis of anti-TB drug-induced hepatotoxicity [ 11 ]. Ferroptosis is a lipid-ROS- … WebFerroptosis is a novel form of regulated cell death (RCD) characterized by the overwhelming iron-dependent accumulation of lipid hydroperoxides. It is morphologically, biochemically, and genetically distinct from other types of RCD.

Web27 jun. 2024 · Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of cell death.

Web20 okt. 2024 · In general, hepatocyte ferroptosis can aggravate the progression of multiple liver diseases, while the ferroptosis of HSCs and HCC cells could repair the damage of … roll of recycling stickersWeb2 feb. 2024 · The precise mechanism by which hepatocyte ferroptosis regulates macrophage STING activation in the progression of liver damage, fibrosis, and … roll of red plastic tablecloth roll of red tableclothWeb14 mrt. 2024 · Ferroptosis is a type of regulated cell death caused by iron overload and lipid peroxidation, and its core is an imbalance of redox reactions. Recent studies … roll of recycled brown paperWeb24 feb. 2024 · Ferroptosis is a newly discovered type of cell death that is caused by a loss of cellular redox homeostasis. As glutathione (GSH) depletion triggers APAP … roll of receipt paperWeb18 okt. 2024 · Ferroptosis in non-alcoholic fatty liver disease/non-alcoholic fatty liver disease-hepatocellular carcinoma Metabolic changes and hepatocyte lip toxicity caused by the ectopic accumulation of free fatty acids (FFAs) in the liver are considered to be the principal causes of liver injury in patients with NAFLD ( 39 ). roll of red plasticWeb6 aug. 2024 · Iron-dependent ferroptosis is characterized by a reduced glutathione level and increased lipid peroxidation. 14,16,53,54 A large number of studies have shown that … roll of red checkered tablecloth