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Web8 jan. 2024 · Importantly, the combination of two small molecules, VPA and EPZ6438, was critical for the induction of the hyperplastic phenotype of Hyper-organoids. The morphological and molecular features of Hyper-organoids, as well as their injury-responsive stem cell populations, nearly disappeared without treatment with these two small … Web18 apr. 2024 · The gradient of these signaling molecules appears to direct tissue … Web29 mei 2012 · Here, we also report a mechanism of hPSC differentiation to cardiomyocytes that solely employs small-molecule activation and inhibition of elements of canonical Wnt signaling by treatment with CHIR99021 or IWP2 at the appropriate temporal stage to guide cells through cardiac development. examples of hypothesis contrary to fact