Pdgf promoter
Splet19. maj 2024 · The most abundant cells in the tumor microenvironment are cancer‑associated fibroblasts (CAFs). They play an important role in oral squamous cell carcinoma (OSCC) angiogenesis, invasion and metastasis. Platelet‑derived growth factor (PDGF)‑BB has an obvious regulating effect on the formation of CAFs through binding to … Splet15. maj 1993 · A transfected reporter gene, consisting of a 1.3-kb fragment of the human PDGF-B promoter coupled to chloramphenicol acetyltransferase (CAT), indicated a direct effect on transcriptional activity. Transfection of a series of PDGF-B-CAT deletion mutants led to the characterization of a cis-acting component within the PDGF-B promoter that …
Pdgf promoter
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Splet17. jul. 2024 · Taken together, our findings suggest that the activation of the PDGF pathway contributes to the pathogenesis of LMNA-related DCM and point to PDGF receptor-β … SpletAbstract. PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases responding to platelet-derived growth factor (PDGF). PDGFRA mutations …
Splet15. mar. 2007 · Transcriptional activity of promoter has been analyzed using several reporter enzymes; chloramphenicol acetyltransferase, luciferase, alkaline phosphatase and β -galactosidase. 15 Recently, it... SpletAbstract. Using cell-type-specific promoters to restrict expression of therapeutic genes to particular cells is an attractive approach for gene therapy, but often hindered by …
SpletPDGF is a mitogen that is potent for cells of mesenchymal origin, which includes fibroblasts, smooth muscle cells, and glial cells. For both mice and humans, the signalling network … Splet18. dec. 2003 · The promoter for platelet-derived growth factor (PDGF) B-chain (PDGF-β promoter) is one such cellular promoter that may offer specific gene expression in …
Splet01. dec. 2012 · All experiments involving the treatment of cells with exogenous PDGF-BB protein were conducted under serum-free conditions since PDGF promoter is known to have serum response elements [28, 29]. To investigate the role of PDGF on MCP-1 expression, A172 cells were treated with recombinant PDGF-BB (20 ng/ml) for the indicated times …
SpletTo address the regulation of PDGF-B gene expression by cyclic strain, we transfected bovine aortic ECs with a construct containing 450 bp of human PDGF-B promoter … cotton heated blanket queenSplet01. feb. 2001 · A 255 bp fragment of the human PDGF-B gene promoter (–252 to +3) with EcoRI and SmaI ends isolated from pUC18promoter was labeled with [α-32 P]dATP at the … breath organic salonSplet30. avg. 2004 · Abstract. Neurogenesis continues in the adult brain and is increased in certain pathological states. We reported recently that neurogenesis is enhanced in hippocampus of patients with Alzheimer's disease (AD). We now report that the effect of AD on neurogenesis can be reproduced in a transgenic mouse model. PDGF-APP Sw,Ind … breathoprene wrist braceSpletDOI: 10.1093/nar/gkm538 Abstract The proximal 5'-flanking region of the human platelet-derived growth factor A (PDGF-A) promoter contains one nuclease hypersensitive … breath or breatheSplet09. sep. 2013 · These transgenic mice express wild-type human APP under the control of the human PDGF-β promoter. They were generated as control mice for the J20 model. … cotton hemstitch napkinsSplet07. jan. 2024 · In this study, we generated a lentiviral vector that produces PDGF-BB under a weak promoter (phosphoglycerate kinase, PGK) and lentiviral vector producing IL-4 under a strong promoter (cytomegalovirus, CMV). cotton hemstitched napkinsSplet01. feb. 2001 · The TFOs appear to specifically interact with the c-sis/PDGF-B gene promoter and repress PDGF-B transcription, since the K562 cell lines transiently and stably transfected with the luciferase gene driven by the same promoter showed dramatically decreased activity. Although we cannot directly demonstrate that triplexes formed inside … breath origin